The 12 acres east of the highway features Historic Faurot Hall housing the Paul Evans Library of Fruit Science, Shepard Hall, the Classroom Building, the Research Winery, the Fruit Processing Education Building, the Sales Dock, Greenhouses, and the Ozark Arboretum. The 180 acres west of highway 95 features the Shop and Machine Storage Building, the Duplex, the Horse Barn, Pine Pond, the Horticulture Demonstration Area, and research and demonstration plantings.
Area students take courses offered on the Mountain Grove campus and through outreach programs from West Plains and Springfield. The VESTA program offers a course of study that leads to a Certificate or Associate of Applied Science Degree in Viticulture or Enology and is offered through Missouri State-West Plains. The Missouri State-West Plains extended campus is located just south of the State Fruit Experiment Station in Shannon Hall.